The aim of this study was to use MRI to evaluate longitudinally changes in the brain in Friedreich's ataxia. 31 patients and 40 controls, were evaluated at baseline and after 1 and 2 years. Patients with Friedreich's ataxia present more widespread gray and white matter damage than previously reported, including not only infratentorial areas, but also supratentorial structures. Furthermore, patients with Friedreich's ataxia have progressive microstructural abnormalities amenable to detection in a short-term follow-up.

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